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Prontosan® vs Neomycin Sprays: Why Prontosan® Is a Better Choice for Wound and Burn Management

Proper wound and burn care is crucial for rapid healing and infection prevention. Among the available options, Prontosan and neomycin sprays are often considered. However, Prontosan offers significant advantages that make it a superior choice in clinical practice and home care.

The composition and mechanism of action of these two products differ significantly. Prontosan contains polyhexamethylene biguanide (PHMB) and beta-glucan, combined with a powerful cleansing system (monopropylene glycol). It is specifically designed for cleaning, disinfecting, and removing biofilm from wound surfaces. On the other hand, neomycin spray contains a traditional broad-spectrum antibiotic that primarily targets bacterial infections. Prontosan not only provides antimicrobial action but also disrupts biofilm and effectively cleans the wound, improving the healing microenvironment and preventing potential infections.

The range of action and resistance of Prontosan is another positive aspect, as it acts against bacteria, fungi, and other pathogens without causing resistance. This makes it ideal for chronic wounds such as chronic ulcers, acute wounds, and burns. In contrast, the continuous use of antibiotics like neomycin sprays can lead to the development of resistant strains of microbes. This makes the use of Prontosan safer in the long term and does not contribute to antibiotic resistance, which is a global health issue.

Prontosan is highly tolerated by the skin and tissues, with minimal reports of allergic reactions or local irritations, making it extremely safe to use. In contrast, neomycin sprays carry the risk of allergic contact dermatitis and toxicity with prolonged use, especially in individuals allergic to aminoglycosides. Prontosan offers a higher safety profile, particularly for long-term use or in patients with allergic sensitivities.


Another feature that makes Prontosan the optimal choice for wound healing is its practical advantage in use. Prontosan is ready to use in solution or gel form, is easy to apply without a burning sensation, and is compatible with all modern wound dressings. Neomycin sprays, however, usually require additional measures such as cleaning and dressing. They also do not clean the wound as they act only bacteriostatically. The practical advantage of Prontosan simplifies wound care and optimizes therapeutic outcomes.

Prontosan is the top choice for wound and burn care, combining effective cleaning, strong disinfection, biofilm prevention, and high patient safety. In contrast, the use of neomycin sprays is limited to simple infections and carries significant risks when used indiscriminately. Choose Prontosan for a holistic and safe healing approach.

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